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Scd1 Inhibitor A939572, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/a939572/pm42208724-48-12-15?v=MedChemExpress
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a939572 t4515  (TargetMol)
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TargetMol a939572 t4515
VA analogues inhibit ferroptosis through the regulation of MUFA metabolism. (A, B) Lipidomic analysis of MUFAs and PUFAs in membrane lipids including PE (A) and PC (B) following VA (5 μmol/L) and D3 (5 μmol/L) treatment for 12 h in HT-1080 cells. (C) Viability HT-1080 cells treated with RSL3 (0.5 μmol/L) and VA (1 μmol/L) or ATRA (10 μmol/L) in the presence or absence of SCD1 inhibitor <t>A939572</t> (20 μmol/L) for 24 h. (D) Validation of SCD1 KO in HT-1080 cells. (E) The levels of OA-CoA were decreased in SCD1 knockout HT-1080 cells. (F) Viability of Vector and SCD1 KO cells treated with RSL3 for 24 h. (G) SCD1 KO compromised the anti-ferroptotic effect of VA analogues in HT-1080 cells. Cells were treated with RSL3 (0.5 μmol/L) and VA (1 μmol/L), ATRA (10 μmol/L) or D3 (5 μmol/L) for 24 h. (H, I) Supplement of OA restored the protective effect of VA analogues against ferroptosis. Vector and SCD1 KO HT-1080 cells were pretreated with OA in (10 and 20 μmol/L in panel H, and 10 μmol/L in panel I, followed by treatment with RSL3 (0.5 μmol/L) and VA (1 μmol/L), ATRA (10 μmol/L) or D3 (5 μmol/L) for 24 h. All the data are presented as the mean ± SD ( n = 3). ∗ P < 0.05, ∗∗∗ P < 0.001, indicating significant differences between groups.
A939572 T4515, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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a939572 t4515 - by Bioz Stars, 2026-08
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scd1 inhibitor a939572  (TargetMol)
94
TargetMol scd1 inhibitor a939572
VA analogues inhibit ferroptosis through the regulation of MUFA metabolism. (A, B) Lipidomic analysis of MUFAs and PUFAs in membrane lipids including PE (A) and PC (B) following VA (5 μmol/L) and D3 (5 μmol/L) treatment for 12 h in HT-1080 cells. (C) Viability HT-1080 cells treated with RSL3 (0.5 μmol/L) and VA (1 μmol/L) or ATRA (10 μmol/L) in the presence or absence of SCD1 inhibitor <t>A939572</t> (20 μmol/L) for 24 h. (D) Validation of SCD1 KO in HT-1080 cells. (E) The levels of OA-CoA were decreased in SCD1 knockout HT-1080 cells. (F) Viability of Vector and SCD1 KO cells treated with RSL3 for 24 h. (G) SCD1 KO compromised the anti-ferroptotic effect of VA analogues in HT-1080 cells. Cells were treated with RSL3 (0.5 μmol/L) and VA (1 μmol/L), ATRA (10 μmol/L) or D3 (5 μmol/L) for 24 h. (H, I) Supplement of OA restored the protective effect of VA analogues against ferroptosis. Vector and SCD1 KO HT-1080 cells were pretreated with OA in (10 and 20 μmol/L in panel H, and 10 μmol/L in panel I, followed by treatment with RSL3 (0.5 μmol/L) and VA (1 μmol/L), ATRA (10 μmol/L) or D3 (5 μmol/L) for 24 h. All the data are presented as the mean ± SD ( n = 3). ∗ P < 0.05, ∗∗∗ P < 0.001, indicating significant differences between groups.
Scd1 Inhibitor A939572, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/a939572/10__7150_slash_ijbs__126269-71-1-5?v=TargetMol
Average 94 stars, based on 1 article reviews
scd1 inhibitor a939572 - by Bioz Stars, 2026-08
94/100 stars
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a939572  (TargetMol)
94
TargetMol a939572
VA analogues inhibit ferroptosis through the regulation of MUFA metabolism. (A, B) Lipidomic analysis of MUFAs and PUFAs in membrane lipids including PE (A) and PC (B) following VA (5 μmol/L) and D3 (5 μmol/L) treatment for 12 h in HT-1080 cells. (C) Viability HT-1080 cells treated with RSL3 (0.5 μmol/L) and VA (1 μmol/L) or ATRA (10 μmol/L) in the presence or absence of SCD1 inhibitor <t>A939572</t> (20 μmol/L) for 24 h. (D) Validation of SCD1 KO in HT-1080 cells. (E) The levels of OA-CoA were decreased in SCD1 knockout HT-1080 cells. (F) Viability of Vector and SCD1 KO cells treated with RSL3 for 24 h. (G) SCD1 KO compromised the anti-ferroptotic effect of VA analogues in HT-1080 cells. Cells were treated with RSL3 (0.5 μmol/L) and VA (1 μmol/L), ATRA (10 μmol/L) or D3 (5 μmol/L) for 24 h. (H, I) Supplement of OA restored the protective effect of VA analogues against ferroptosis. Vector and SCD1 KO HT-1080 cells were pretreated with OA in (10 and 20 μmol/L in panel H, and 10 μmol/L in panel I, followed by treatment with RSL3 (0.5 μmol/L) and VA (1 μmol/L), ATRA (10 μmol/L) or D3 (5 μmol/L) for 24 h. All the data are presented as the mean ± SD ( n = 3). ∗ P < 0.05, ∗∗∗ P < 0.001, indicating significant differences between groups.
A939572, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/a939572/10__7150_slash_ijbs__126269-114-54-56?v=TargetMol
Average 94 stars, based on 1 article reviews
a939572 - by Bioz Stars, 2026-08
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a939572  (MedChemExpress)
95
MedChemExpress a939572
VA analogues inhibit ferroptosis through the regulation of MUFA metabolism. (A, B) Lipidomic analysis of MUFAs and PUFAs in membrane lipids including PE (A) and PC (B) following VA (5 μmol/L) and D3 (5 μmol/L) treatment for 12 h in HT-1080 cells. (C) Viability HT-1080 cells treated with RSL3 (0.5 μmol/L) and VA (1 μmol/L) or ATRA (10 μmol/L) in the presence or absence of SCD1 inhibitor <t>A939572</t> (20 μmol/L) for 24 h. (D) Validation of SCD1 KO in HT-1080 cells. (E) The levels of OA-CoA were decreased in SCD1 knockout HT-1080 cells. (F) Viability of Vector and SCD1 KO cells treated with RSL3 for 24 h. (G) SCD1 KO compromised the anti-ferroptotic effect of VA analogues in HT-1080 cells. Cells were treated with RSL3 (0.5 μmol/L) and VA (1 μmol/L), ATRA (10 μmol/L) or D3 (5 μmol/L) for 24 h. (H, I) Supplement of OA restored the protective effect of VA analogues against ferroptosis. Vector and SCD1 KO HT-1080 cells were pretreated with OA in (10 and 20 μmol/L in panel H, and 10 μmol/L in panel I, followed by treatment with RSL3 (0.5 μmol/L) and VA (1 μmol/L), ATRA (10 μmol/L) or D3 (5 μmol/L) for 24 h. All the data are presented as the mean ± SD ( n = 3). ∗ P < 0.05, ∗∗∗ P < 0.001, indicating significant differences between groups.
A939572, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/a939572/pm41458042-37-10-11?v=MedChemExpress
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a939572 - by Bioz Stars, 2026-08
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VA analogues inhibit ferroptosis through the regulation of MUFA metabolism. (A, B) Lipidomic analysis of MUFAs and PUFAs in membrane lipids including PE (A) and PC (B) following VA (5 μmol/L) and D3 (5 μmol/L) treatment for 12 h in HT-1080 cells. (C) Viability HT-1080 cells treated with RSL3 (0.5 μmol/L) and VA (1 μmol/L) or ATRA (10 μmol/L) in the presence or absence of SCD1 inhibitor A939572 (20 μmol/L) for 24 h. (D) Validation of SCD1 KO in HT-1080 cells. (E) The levels of OA-CoA were decreased in SCD1 knockout HT-1080 cells. (F) Viability of Vector and SCD1 KO cells treated with RSL3 for 24 h. (G) SCD1 KO compromised the anti-ferroptotic effect of VA analogues in HT-1080 cells. Cells were treated with RSL3 (0.5 μmol/L) and VA (1 μmol/L), ATRA (10 μmol/L) or D3 (5 μmol/L) for 24 h. (H, I) Supplement of OA restored the protective effect of VA analogues against ferroptosis. Vector and SCD1 KO HT-1080 cells were pretreated with OA in (10 and 20 μmol/L in panel H, and 10 μmol/L in panel I, followed by treatment with RSL3 (0.5 μmol/L) and VA (1 μmol/L), ATRA (10 μmol/L) or D3 (5 μmol/L) for 24 h. All the data are presented as the mean ± SD ( n = 3). ∗ P < 0.05, ∗∗∗ P < 0.001, indicating significant differences between groups.

Journal: Acta Pharmaceutica Sinica. B

Article Title: Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3

doi: 10.1016/j.apsb.2025.11.004

Figure Lengend Snippet: VA analogues inhibit ferroptosis through the regulation of MUFA metabolism. (A, B) Lipidomic analysis of MUFAs and PUFAs in membrane lipids including PE (A) and PC (B) following VA (5 μmol/L) and D3 (5 μmol/L) treatment for 12 h in HT-1080 cells. (C) Viability HT-1080 cells treated with RSL3 (0.5 μmol/L) and VA (1 μmol/L) or ATRA (10 μmol/L) in the presence or absence of SCD1 inhibitor A939572 (20 μmol/L) for 24 h. (D) Validation of SCD1 KO in HT-1080 cells. (E) The levels of OA-CoA were decreased in SCD1 knockout HT-1080 cells. (F) Viability of Vector and SCD1 KO cells treated with RSL3 for 24 h. (G) SCD1 KO compromised the anti-ferroptotic effect of VA analogues in HT-1080 cells. Cells were treated with RSL3 (0.5 μmol/L) and VA (1 μmol/L), ATRA (10 μmol/L) or D3 (5 μmol/L) for 24 h. (H, I) Supplement of OA restored the protective effect of VA analogues against ferroptosis. Vector and SCD1 KO HT-1080 cells were pretreated with OA in (10 and 20 μmol/L in panel H, and 10 μmol/L in panel I, followed by treatment with RSL3 (0.5 μmol/L) and VA (1 μmol/L), ATRA (10 μmol/L) or D3 (5 μmol/L) for 24 h. All the data are presented as the mean ± SD ( n = 3). ∗ P < 0.05, ∗∗∗ P < 0.001, indicating significant differences between groups.

Article Snippet: All- trans -retinal (T5256), Fenretinide (T1872), Acitretin (T1330), AGN193109 (TQ0097), HX531( T22843 ), Ch55 ( T14946 ), Adapalene (T1093) and A939572 (T4515) were purchased from TargetMOI (Shanghai, China).

Techniques: Analogues, Membrane, Biomarker Discovery, Knock-Out, Plasmid Preparation